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Isolated perfusion with 1.0 g/kg of the cytotoxic xenobiotic 5-FU or hyperthermia of 41 degrees C × 10 min resulted in 90% to 100% mortality in rats, with extensive, patchy necrosis, and infarction on histologic examination (Miyazaki et al
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Leucine has also been found to be a potent amino acid effective in reducing skeletal muscle catabolism
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