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After differentiating from monocytes through the actions of CD36 and SR-A1 scavenger receptors, macrophages can recognize and uptake ox-LDLs, thereby activating their expressions as well [31]

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While IGF-I remains the biomarker that best reflects endogenous GH secretion, when there is a discordancy with GH and IGF-I levels, it is important for the clinician to be mindful of the associated changes in intra-portal insulin delivery to the liver when interpreting these results in the context of health and when deciding treatment regimens in disease states