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After two years of observation and experiments, they found that chemoradiotherapy affected epithelial cells by inducing DNA and non-DNA damage, activated reactive oxygen species and activated TLR4/NF-ΚB pathway, promoted the production of TNF-α, IL-1β and IL-6, and accelerated apoptosis, in addition, TNF-A, IL-6, IL-1β, and apoptosis play a central role in the development of mucositis, and IL-6 levels are positively correlated with the severity of OM in radiotherapy patients taken together (53), probiotic mixtures can reduce TLR4/NFΚB activity and slow inflammation and apoptosis induced by chemotherapy and radiotherapy