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Ethinylestradiol administration to TR rats further increased plasma BA concentrations as a result of reduced BA uptake and increased efflux via reduced Slco1a1 and upregulated Mrp4 transporters

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Further investigations into CdhR-like, CaiF-like and the predicted carnitine-sensing TetR family regulators in Gram-positives will be needed to understand how ligand detection is accomplished and converted into regulation of gene expression

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