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Where cysteine residues are present as free thiols rather than paired, they are the most reactive feature in the molecule and will oxidize on standing in neutral to alkaline aqueous solution with atmospheric oxygen available, producing intramolecular or intermolecular disulfide species that are chemically distinct from the starting material

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[DOI] [PubMed] [Google Scholar] 134.Bertino L., Guarneri F., Cannavò S.P., Casciaro M., Pioggia G., Gangemi S

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