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8 Future directions Conventional antioxidants face limitations in efficacy and specificity, but emerging strategies—including mitochondria-targeted compounds and Nrf2 activators—address these challenges through three transformative mechanisms: • Precision targeting Unlike broad-acting scavengers, these agents accumulate within mitochondria, the primary source of ROS

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A protein that can sense DNA in the cytosol and orchestrate a downstream immune response by binding to other signalling proteins