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Although the addition of CTP restored CTP levels in the CTPS1-KO cells, DNA repair efficiency was not restored to basal levels, indicating that the role of CTPS1 in the DDR is independent of CTP synthesis activity (Extended Data Fig

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Although some studies have shown that inhibiting ferroptosis has an anti-depressive function, the specific mechanisms by which ferroptosis is regulated in MDD remain to be fully elucidated