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Allameh, A., Niayesh-Mehr, R., Aliarab, A., Sebastiani, G

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The rate-limiting enzyme in this pathway is Indoleamine 2,3-dioxygenase 1 (IDO-1), which is upregulated by pro-inflammatory agents such as interferon-γ (IFN-γ) and tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-12 (IL-12), all cytokines that are released during inflammatory responses (Yang et al., 2024)