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Loss-of-function mutations in TET2 disrupt the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), resulting in aberrant DNA hypermethylation, silencing of tumor suppressor genes, and impaired cellular differentiation (219)

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Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar