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In supraphysiological concentrations, which are achievable with practical and well-tolerated high-dose supplementation, the B vitamin biotin can directly activate sGC – mimicking the physiological effects of nitric oxide and carbon monoxide in that regard
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In a historical cohort of 241 major surgical procedures there were 14 post-operative thromboembolic events with four being fatal (Mudd et al 1985)
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