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Metabolism & Elimination The metabolic fate of AHK-Cu has not been comprehensively studied in living systems: Peptide degradation : As a tripeptide, AHK-Cu is susceptible to peptidase activity that would cleave peptide bonds Copper dissociation from the peptide complex may occur under certain pH and ionic conditions Half-life in tissue following topical application is likely measured in minutes to hours based on peptide class characteristics Systemic absorption following topical use is expected to be minimal given typical formulation approaches The relationship between application frequency, tissue retention, and sustained biological effects requires systematic investigation
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