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Illustratively, BPC 157 counteracted lidocaine convulsions [60], and thereby, likely also lidocaine’s effects on the central nervous system (i.e., inhibiting nicotinic acetylcholine receptors, inhibiting presynaptic calcium channels in the dorsal root ganglion, inhibiting opioid receptors, inhibiting of neurite growth, inhibiting muscarinic cholinergic receptors, and preventing substance P from binding to natural killer (NK) cell receptors) [278,281,282,283]

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While cagrilintide elicited an anorectic response in WT mice that persisted only for the first day of treatment, no such effect was observed in RAMP1/3 KO mice