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This duality is further complicated by evidence that impaired autophagy activates NF-κB through sequestosome 1 (SQSTM1/p62) accumulation, which upregulates NNMT, creating a feedback loop that depletes NAD + and intensifies oxidative stress [14]

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Drone strikes damage three Amazon data centers, causing major disruptions Amazon Web Services is experiencing significant disruption in the Middle East after three of its data centers were hit with drone strikes, the company said this evening