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418 Tumor cells promote angiogenesis by secreting VEGFs, stabilized by HIF-1α in a hypoxic TME, 84,419 while oncogenes such as RAS and RAF (Fig

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vtc2 mutants with ~ 20% of wild type ascorbate grow nearly as well as WT [206] although the widely-used vtc2-1 allele is small [205], [207]