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There are five members of the sodium-independent glucose transporters in the brain, including GLUT-1 (ECs), GLUT-3 (neurons), 43 and GLUT-5 (microglia)

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In glioblastoma, ferroptosis presents a unique vulnerability, as tumor cells exhibit ferroaddiction, an increased dependence on iron (Fe 2+ ) for metabolic functions, yet simultaneously deploy protective mechanisms to evade ferroptotic cell death (Fig