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Oxidative Stress Early in Pregnancy and Pregnancy Outcome

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This action appears to result from a combination of mechanisms including: blocking Na+ channels (possibly the most important mechanism) enhancing GABA-mediated inhibition in the CNS (by increasing GABA levels by a variety of mechanisms) increase in K+ currents block of T-type Ca2+ channels blockade of excitatory NMDA receptor-mediated excitation NOTE: sodium valproate is the salt form of valproic acid