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This metabolic adaptation can be relevant in triple-negative breast cancers (those lacking ERs, PRs and HER2, which constitute approximately a quarter of breast tumours) that express xCT, which exhibit increased levels of ROS induced by decreased glutamate levels upon glutamine scarcity
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Expanding these findings, a recent study explored the relationship between body composition and AER in females, also using the intravenous alcohol clamp (116)
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