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We showed previously that folic acid is a synthetic compound with no biological functions until it is transformed to functional folate inside the body, and thus it causes higher level of unmetabolised folic acid in the blood with harmful effects

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Increasing evidence suggests that diet, mainly one that is rich in omega-3 polyunsaturated fatty acids (ω-3 PUFAs), plays a significant role in brain health [18,19] and may be beneficial in managing CI in COPD patients [19]