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Oral absorption of curcumin is generally poor due to its low solubility and instability in the intestinal environment

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Critical Appraisal, Limitations, and Challenges in Network Pharmacology Studies The network analysis model often limits itself to intracellular communications and does not include extracellular communications and interactions between various physiological regulatory systems, such as the integrative nervous, endocrine, immune, cardiovascular, respiratory, and renal systems in various organs and tissues