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Consistent with this, our preclinical work uncovered that TMAO primed renal fibroblasts for conversion to myofibroblasts, the primary collagen-producing cells in the kidney 46 , and contributed to renal fibrosis, a hallmark of kidney damage irrespective of the underlying cause that significantly contributes to eGFR decline 46
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DOI: 10.1038/s41598-019-46387-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 61.Gottlieb MA
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