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In vitro studies using alpha mouse liver (AML12) hepatocyte cells further confirmed this mechanism: NNMT knockdown increased SAM and SAH levels, reduced 1-MNA production, and downregulated Srebf1 (sterol regulatory element-binding protein 1 [SREBP1]), a key lipogenic gene

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Ketamine induces lasting antidepressant effects by modulating the NMDAR/CaMKII-mediated synaptic plasticity of the hippocampal dentate gyrus in depressive stroke model