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Transplantation using Autologous Bone Marrow-derived Stem Cells In a single randomized controlled trial involving 32 ASD children aged 5-15 years, they were randomly assigned to receive either autologous bone marrow MSCs (BMMSCs) combined with rehabilitation treatment and risperidone or only rehabilitation therapy and risperidone [92]

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Epithelial – immune cell metabolic circuits As mentioned above, tryptophan is catabolized by Ido1 in IECs as well as lamina propria immune cells, generating immunoregulatory kynurenine-based metabolites and resulting in tryptophan depletion

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