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Besides, Suyin Detoxification Granule (SDG) have been found to prevent the progression of CKD by regulating intestinal microbiota, reducing circulating TMAO levels, inhibiting increased renal tubular iron concentration, suppressing pro-fibrotic factor secretion, and mitigating TMAO-induced renal fibrosis (Li et al., 2021), naringenin, paeoniflorin, beta-ecdysterone, 18beta-glycyrrhetinic acid, bitter amygdalin, leucovorin, shiba hu saponin A (Yu et al., 2021), Perilla frutescens L (Yong et al., 2023), and a number of herbal formulas (Ji et al., 2020