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For example, relevant particles less than 2.5 μM in diameter activate the epidermal growth factor receptor (EGFR) system ( 3.1 Effects of juglone on marine organisms Juglone (5-hydroxy 1,4-naphthoquinone) and also its derivative plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) were reported to have the most significant toxicity against most aquatic organisms (Wright et al., 2007a)