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Diffusion tensor imaging (DTI) analyses have revealed microstructural abnormalities in white matter tracts implicated in pain modulation, such as the spinothalamic tract and corpus callosum, suggesting altered structural connectivity that may underpin abnormal pain processing [29]

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Thermo Fisher Scientific), and 100 μg of the sample was transferred into a new tube and adjusted to a final volume of 100 μl with 100 mM TEAB