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These data also show that with an agonist alone, the receptor does not simply populate a mixture of the inactive and active crystallographic conformations but adopts new, intermediate conformations, particularly in the vicinity of M215 5.54 and M279 6.34 , near the cytoplasmic ends of TM5 and TM6, respectively

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Studies confirm the link between low GSH and cognitive impairment: Closely tied to this is glutathione’s role in mitochondrial survival