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As such, future translational efforts should be directed to evaluate the polytherapy consisting of anti-inflammatory agents and current ASDs to determine whether targeting neuroinflammation can improve the pharmaco-sensitivity to ASDs for drug-resistant epilepsy

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Only adjunctive N-acetylcysteine (NAC) was found to have a statistically significant antidepressant effect, but this was based on a single study and not a pooled sample (Berk et al., 2019)