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neuropathy), effective replacement therapy should lead to a normal full blood count and B12 level after 8 weeks of treatment, while improvement in neurological symptoms begins very quickly – within one week of initiation of therapy – but can take up to 3 months to resolve (Carmel, 2008)

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identified a highly potent and selective first-in-class catalytic inhibitor of METTL3, STM2457, which reduces acute myeloid leukemia growth and increases differentiation and apoptosis by selectively reducing m 6 A levels on known leukemogenic mRNAs [49]