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BOX 1 The immunobiology of MS The immune-mediated biology of MS identifies a prominent role of peripherally-derived T and B cells in acute active demyelinating lesions, with microglia, macrophages and astrocytes mainly responsible for chronic inflammation (Rodríguez Murúa et al., 2022

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Oxidative damage indices, most notably 8-OHdG modification burden in leukocyte mtDNA, correlate with SLEDAI scores and anti-dsDNA titers, suggesting their potential utility as markers of disease activity and cumulative oxidative stress (118, 119)