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Such interactions can lead to the inactivation of enzymes that are important in energy production and amino acid metabolism, such as the tricarboxylic acid cycle enzyme aconitase (Scandroglio et al
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[59] Nintedanib [edit] Nintedanib is a triple angiokinase inhibitor that targets receptor tyrosine kinases involved in the regulation of angiogenesis: fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR), [60] which have also been implicated in the pathogenesis of fibrosis and IPF
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