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This mechanism of inhibiting proteasome activity may be achieved by targeting nuclear protein localization protein 4 homolog (NPL4), which is the adapter factor for the p97 (also known as VCP) segregase, involved in the conversion of proteins involved in multiple regulatory and stress response pathways (198)
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Early concerns that antihypertensives or ibuprofen might exacerbate COVID-19 severity have not been substantiated
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