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for instance, case reports have demonstrated survival after a 25 g overdose [42] , and current guidelines in the United States and Canada indicate a high-risk ingestion to be ingestion of at least 30 g of APAP [43]
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In contrast, in PA-stimulated HepG2 cells, Sesn2 knockdown significantly suppressed empagliflozin-mediated changes in inflammatory cytokines and AMPK/mTOR signalling, suggesting that empagliflozin-mediated inflammation is partially dependent on Sesn2 expression
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