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MeHg interacts with (and oxidize) nucleophilic groups present in proteins or low-molecular weight molecules and such interactions modify the redox state of these groups, leading to oxidative stress, impaired function and neurotoxicity

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135 , 137 Huang et al designed a complex of DNA and cationic polyethyleneimine nanoparticles (DNPs), which were found to stimulate the upregulation of indoleamine 2,3-dioxygenase (IDO) activity, further inducing DCs and regulatory T cells (Tregs) to suppress immune overexpression in inflamed joints, demonstrating strong immune-modulatory properties