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[49] found that hibiscus leaf polyphenols abrogated TNF-induced matrix MMP-9 expression and migration and proliferation of VSMCs by inhibiting the PKB (also known as Akt)/activator protein-1 (AP-1) pathway (Table 1)
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Beyond physicochemical properties, targeted delivery strategies and further functionalization of degrader molecules could help to overcome challenges stemming from poor selectivity or permeability
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